We own a very large dog (Anatolian Shepard cross).
He is fine in our 2010 Avensis estate since we adopted him in 2016, can stand, sit and turn around.
Due to the dog size he is blocking the back mirror as the floor is fairly high in this model but this is not an issue for me and the Mrs's as we both drove vans and lorries.
In our previous estate (2003 Passat) there was a bit more standing up room.
IMHO the nicest car for a large dog covering both height and overall compartment size is the Volvo V70 or X70, I'll have one tomorrow but don't want diesels and I don't think the reliability will exceed the Avensis.
Most medium size SUV's we looked at have a boot too short for a large dog to turn around comfortably. A large money pit SUV's like the Range Rover or Disco will do well to carry a large beast.
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