First of all he needs to inform the DVLA of his amputation. This is dealt with by a specialist medical section of the DVLA. I have been dealing with them since I became disabled in 1983. On occasions they are difficult to deal with and are very slow in responding, but remember they apply the rules and must issue the licence before you can drive again.
Most likely he will get his full manual licence retained but will have a licence code applied to it. www.gov.uk/driving-licence-codes Most likely for a left leg amputation a code 35 - Modified control layout.
No reason why he cannot ride a motorcycle or bicycle with one leg. I do despite losing my right leg above the knee in 1983. DVLA still issue me with full manual licence but with a code 32 for cars and code 44(3) applied for Motorcycles.
There are a few places to get modifications done. I would endorse kliktronic mentioned above. Noticed recently a few new bikes coming with quickshifters which I suppose overcomes a left foot disability.
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